General description

FTO (Fat mass-and obesity-associated gene) is the responsible gene for mouse ‘;fused toes’; mutation. An association between FTO genotype and type 2 diabetes has been confirmed. The presence of the FTO rs9939609 A-allele was found to be positively correlated with other symptoms of the metabolic syndrome, including higher fasting insulin, glucose, triglycerides, and lower HDL-cholesterol.

Physical form

0.5 mg/mL of 0.2 µm-filtered solution in 55 mM Tris-Cl, pH 8.2 containing 150 mM NaCl.