Biochem/physiol Actions

Cell permeable: no

Reversible: no

Product does not compete with ATP.

Primary TargetAmyloidophilic fluorescent probe

General description

A fluorine analog of the amyloidophilic fluorescent probe BSB (Cat. No. 286895) that crosses the blood-brain barrier and displays low toxicity (LD₅₀ >80 mg/kg). Suitable for non-invasive amyloid visualization in living transgenic Tg2576 mice by using ¹⁹F and ¹H-MRI (Magnetic Resonance Imaging). Also useful for staining plaques and neurofibrillary tangles in brain tissue sections of Alzheimer′s diseased patients with improved sensitivity, and reduced background.

This fluorine analog of the amyloidophilic fluorescent probe BSB (Cat. No. 286895) crosses the blood-brain barrier and displays low toxicity (LD₅₀ >80 mg/kg). Suitable for non-invasive amyloid visualization in living transgenic Tg2576 mice by using ¹⁹F and ¹H-MRI. Also useful for staining plaques and neurofibrillary tangles in brain tissue sections of Alzheimer′s diseased patients, with improved sensitivity and reduced background.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Other Notes

Higuchi, M., et al. 2005. Nat. Neurosci.8, 527.Sato, K., et al. 2004. Eur. J. Med. Chem.39, 573.

Packaging

Packaged under inert gas

5 mg in Plastic ampoule

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Warning

Toxicity: Standard Handling (A)