Biochem/physiol Actions

Cell permeable: no

Reversible: no

Primary TargetSelective inhibitor of the γ-isoform of alcohol dehydrogenase

Product does not compete with ATP.

General description

A non-steroidal phytoestrogenic isoflavone found in soy-based food products. Has been shown to interact with human estrogen receptor with relatively low potency. Induces mammary gland proliferation in mice. Inhibits lecithin peroxidation induced by hydroxyl radicals. Also acts as a selective inhibitor of γ-isoform of alcohol dehydrogenase.

A phytoestrogenic isoflavone found in soy-based foods. Displays potent antioxidant properties and acts as a selective inhibitor of the γ-isoform of alcohol dehydrogenase. Shown to interact with human estrogen receptors with low potency. Induces mammary gland proliferation in mice.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Other Notes

Pool-Zobel, B.L., et al. 2000. Carcinogenesis 21, 1247.Toda, S., and Shirataki, Y. 1999. Phytother. Res.13, 163.Ruiz-Larrea, M.B., et al. 1997. Free Radic. Res.26, 63.Keung, W.M. 1995. Biochem. Biophys. Res. Commun.215, 1137.Wang, W., et al. 1995. Nutr. Cancer23, 131.Miksicek, R.J. 1994. J. Steroid Biochem. Mol. Biol.49, 153.

Packaging

Packaged under inert gas

5 mg in Plastic ampoule

Reconstitution

Following reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C. Do not re-freeze any thawed aliquots.

Warning

Toxicity: Irritant (B)