Application

Fmoc-L-Photo-Leucine is a diazirine-containing, Fmoc-protected leucine amino acid and multifunctional photo-crosslinker. Its incorporation into peptides or small-molecule probes and tools allows for photoaffinity labeling of cellular targets and protein-protein interactions upon UV light (~360 nm) irradiation to form a covalent bond. This and other multifunctional probe building blocks will continue to accelerate drug discovery research for probing cellular mechanisms, target ID/validation, and understanding traditionally undruggable targets. An unprotected version is also available as 907278.

Other Notes

Synthesis of a polymyxin derivative for photolabeling studies in the gram-negative bacterium Escherichia coliDeveloping diazirine-based chemical probes to identify histone modification ′readers′ and ′erasers′Protein-Polymer Conjugation via Ligand Affinity and Photoactivation of Glutathione S-TransferaseFishing for Drug Targets: A Focus on Diazirine Photoaffinity Probe SynthesisPhoto-affinity labeling (PAL) in chemical proteomics: a handy tool to investigate protein-protein interactions (PPIs)