Etoposide

Biochem/physiol Actions

Target IC₅₀: 59.2 µM inhibiting topoisomerase II

Reversible: no

Product does not compete with ATP.

Primary Targettopoisomerase 2

Cell permeable: yes

General description

A cell-permeable, topoisomerase II inhibitor (IC₅₀ = 59.2 µM). A derivative of podophyllotoxin (Cat. No. 540040) that has major activity against a number of tumors, including germ cell neoplasms, small cell lung cancer, and malignant lymphoma. Induces apoptosis in mouse thymocytes and in HL-60 human leukemia cells.

A cell-permeable derivative of podophyllotoxin that acts as a topoisomerase II inhibitor (IC₅₀ = 59.2 µM) has major activity against a number of tumors, including germ cell neoplasms, small cell lung cancer, and malignant lymphoma. Induces apoptosis in mouse thymocytes and in HL-60 human leukemia cells.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Other Notes

De Lange, A.M., et al. 1995. J. Virol. 69, 2082.Kaufman, S.H., et al. 1993. Cancer Res.53, 3976.Onishi, Y., et al. 1993. Biochim. Biophys. Acta1175, 147.Terada, T., et al. 1993. J. Med. Chem. 36, 1689.Wazniak, A.J., et al. 1991. J. Clin. Oncol.9, 70.Einhorn, L.H., et al. 1988. J. Clin. Oncol.6, 451.Issel, B.F. 1982. Cancer Chemother. Pharmacol.7, 73.

Packaging

25 mg in Plastic ampoule

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Warning

Toxicity: Harmful & Carcinogenic / Teratogenic (E)