Erastin

General description

A cell-permeable piperazinyl-quinazolinone compound that exhibits oncogene-selective lethality. Shown to bind mitochondrial voltage-dependent anion channels (VDAC) and alter its gating; rapidly induce an oxidative, non-apoptotic cell death in several human tumors harboring activating mutations in the RAS-RAF-MEK signaling (EC₅₀ = 6.0 µM in BJ-TERT/LT/ST/RAS^V12 cells).

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Other Notes

Yagoda, N., et al. 2007. Nature447, 864.

Packaging

Packaged under inert gas

5 mg in Plastic ampoule

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Warning

Toxicity: Standard Handling (A)