Biochem/physiol Actions

Reversible: no

Product does not compete with ATP.

Primary Targettopoisomerase 2

Cell permeable: yes

General description

A topoisomerase II inhibitor. Acts as an intercalative alkaloid that stimulates topoisomerase II-mediated DNA breakage. Is also capable of uncoupling mitochondrial oxidative phosphorylation.

A cell-permeable antitumor alkaloid that acts as an inhibitor of topoisomerase II and acts as an intercalative agent that stimulates topoisomerase II-mediated DNA breakage. Is also capable of uncoupling mitochondrial oxidative phosphorylation.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Other Notes

Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.

Froelich-Ammon, S.J., et al. 1995. J. Biol. Chem. 270, 14998.Schwaller, M.A., et al. 1995. J. Biol. Chem.270, 22709.Pommier, Y., et al. 1985. Biochemistry24, 6406.

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Warning

Toxicity: Toxic & Carcinogenic / Teratogenic (G)