Biochem/physiol Actions

Primary TargetmGlu₅

General description

A positive allosteric modulator for mGlu receptor subtype 5 (EC₅₀ = 2 - 5.3 µM). No agonistic action on mGlu₅. Renders 3-6 fold potentiation for Glu5 agonists. No effect on other mGlu receptor subtypes.

A positive allosteric modulator for mGlu receptor subtype 5 (EC₅₀ = 2 - 5.3 µM). No agonistic action on mGlu₅. Renders 3-6 fold potentiation for Glu5 agonists. No effect on other mGlu receptor subtypes.Please note that the molecular weight for this compound is batch-specific due to variable water content.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Other Notes

O'Brien, J., et al. 2003. Mol. Pharmacol.64, 731.Zhang Z., et al. 2005. J. Pharmacol. Exp. Ther.315, 1212.

Packaging

Packaged under inert gas

10 mg in Glass bottle

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Warning

Toxicity: Standard Handling (A)