DACOMITINIB

Code: PZ0330-25MG D2-231

Biochem/physiol Actions

Dacomitinib (PF-00299804) is an irreversible EGFR inhibitor and antineoplastic. It is a potent inhibitor of HER-1 (EGFR), -2 and -4 tyrosine kinase wi...


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€522.80 25MG
€643.04 inc. VAT

Biochem/physiol Actions

Dacomitinib (PF-00299804) is an irreversible EGFR inhibitor and antineoplastic. It is a potent inhibitor of HER-1 (EGFR), -2 and -4 tyrosine kinase with IC50s of 6.0, 45.7 and 73.7 nM respectively for EGFR, ERBB2 and ERBB4. Dacomitinib is believed to irreversibly inhibit erbB tyrosine kinase activity through binding at the ATP site and covalent modification of nucleophilic cysteine residues in the catalytic domains of erbB family members.

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Pfizer is a registered trademark of Pfizer, Inc.

Sold for research purposes under agreement from Pfizer Inc.

assay≥98% (HPLC)
colorwhite to beige
formpowder
manufacturer/tradenamePfizer®
originatorPfizer
Quality Level100
solubilityDMSO: 2 mg/mL, clear
storage temp.room temp
Cas Number1110813-31-4
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