Biochem/physiol Actions

Cell permeable: no

Reversible: no

Product does not compete with ATP.

Primary TargetA competitive antagonist of Capsaicin and resiniferatoxin

General description

A competitive antagonist of Capsaicin (Cat. No. 211274) and resiniferatoxin. Capsazepine (1 µM) blocks capsaicin (60 nM) stimulated firing of C-fibers.

A competitive antagonist of the sensory neuron excitants capsaicin (Cat. No. 211274) and resiniferatoxin (Cat. No. 553975). Capsazepine (1 µM) blocks capsaicin (60 nM) stimulated firing of C-fibers.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Other Notes

Fox, A.J., et al. 1995. Neuroscience 67, 741.Ellis, J.L., and Undem, B.J. 1994. J. Pharmacol. Exp. Ther. 268, 85.Walpole, C.S.J., et al. 1994. J. Med. Chem.37, 1942.Szallasi, A., et al. 1993. J. Pharmacol. Exp. Therap.267, 728.

Packaging

10 mg in Plastic ampoule

Reconstitution

Unstable in solution; reconstitute just prior to use.

Warning

Toxicity: Standard Handling (A)