CZC24832

Code: SML1214-5MG D2-231

Biochem/physiol Actions

CZC24832 is a potent and selective inhibitor of phosphoinositide 3-kinase γ (PI3Kγ) with Kd app of 19 nM. CZC24832 is said to be the first s...


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€128.22 5MG
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Biochem/physiol Actions

CZC24832 is a potent and selective inhibitor of phosphoinositide 3-kinase γ (PI3Kγ) with Kd app of 19 nM. CZC24832 is said to be the first selective PI3Kγ inhibitor with efficacy in in vitro and in vivo models of inflammation. CZC24832 strongly inhibited T-cell interleukin 17A (IL-17A) production by inhibiting expression of retinoic acid receptor–related orphan receptor γt (RORγt), a transcription factor that drives TH17 differentiation, showing a new role for PI3Kγ.

assay≥98% (HPLC)
colorwhite to beige
formpowder
InChI keyRXRZPHQBTHQXSV-UHFFFAOYSA-N
InChI1S/C15H17FN6O2S/c1-15(2,3)21-25(23,24)11-4-9(6-18-7-11)10-5-12(16)13-19-14(17)20-22(13)8-10/h4-8,21H,1-3H3,(H2,17,20)
Quality Level100
SMILES stringFC1=CC(C2=CN=CC(S(NC(C)(C)C)(=O)=O)=C2)=CN3C1=NC(N)=N3
solubilityDMSO: 10 mg/mL, clear
storage temp.−20°C
Cas Number1159824-67-5
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