Biochem/physiol Actions

Primary TargetNMDA receptors

Target IC₅₀: 0.039 µM for NR2B and >100 µM for NR2A, NR2C, and NR2D

General description

A highly selective antagonist for NR2B subunit containing NMDA receptors (IC₅₀ = 0.039 µM for NR2B and >100 µM for NR2A, NR2C, and NR2D). Widely used as neuroprotective, analgesic, antidepressant, and anti-Parkinsonian agent in research.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Other Notes

Taniguchi, K., et al. 2009. British J. Pharmacol.122, 809.Menniti, F., et al. 1997. Eur. J. Pharmacol.331, 117.r>Nicholson, K., et al. 2007. Behavioural Pharmacology18, 731.Bullock, M., et al. 2006. Annals of the New York Academy of Sciences890, 51.r>Preskorn, S., et al. 2008. J. Clin. Psychopharmacol.28, 631.r>Yurkewicz, L., et al. 2005. J. Neurotrauma.22, 1428.

Packaging

5 mg in Glass bottle

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Warning

Toxicity: Standard Handling (A)

assay	≥98% (HPLC)
color	white
form	powder
InChI key	QEMSVZNTSXPFJA-HNAYVOBHSA-N
InChI	1S/C20H25NO3/c1-15(19(23)16-7-9-18(22)10-8-16)21-13-11-20(24,12-14-21)17-5-3-2-4-6-17/h2-10,15,19,22-24H,11-14H2,1H3/t15-,19+/m0/s1
manufacturer/tradename	Calbiochem^®
Quality Level	100
solubility	DMSO: 35 mg/mL
storage condition	protect from light, OK to freeze
storage temp.	2-8°C