General description
A blood brain barrier permeable, positive allosteric modulator of the metabotropic GABAB receptor. Shown to modulate GABAB receptor in the high affinity state and thereby increases agonist affinity for the receptor. Also enhances agonist potency and efficacy even on recombinant GABAB receptors. Exhibits anxiolytic effects in rodents.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Other Notes
Adams, C. et al., 2007. CNS Drug Rev.13, 308.Pin, J.P., et al., 2007. Curr. Neuropharmacol.5, 195.
Packaging
10 mg in Glass bottle
Warning
Toxicity: Standard Handling (A)
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