Biochem/physiol Actions

Cluster of differentiation 58 (CD58)/lymphocyte function-associated antigen 3 (LFA-3) is a ligand of the T-lymphocyte cluster of differentiation 2 (CD2) glycoprotein, which binds to CD2 (LFA-2) on T cells. It is important in strengthening the adhesion between the T cells and professional antigen presenting cells. In addition, the LFA-3/CD2 interaction may prime response by both the CD2⁺ and LFA-3⁺ cells. Polymorphisms in the CD58 gene are associated with increased risk for multiple sclerosis.

General description

Cluster of differentiation 58 (CD58), also known as lymphocyte function-associated antigen 3 (LFA-3), is a cell adhesion molecule expressed on antigen presenting cells (APC), particularly macrophages. The gene encoding this protein is localized on human chromosome 1p13.1. CD58 /LFA3 is ligand of the T-lymphocyte CD2 glycoprotein, which binds to CD2 (LFA-2) on T cells and is important in strengthening the adhesion between the T cells and Professional Antigen Presenting Cells. In addition, the LFA-3/CD2 interaction may prime response by both the CD2⁺ and LFA-3⁺ cells. Polymorphisms in the CD58 gene are associated with increased risk for multiple sclerosis.

Physical form

Lyophilized from 0.22 µm filtered solution in PBS, pH7.4. Normally Mannitol or Trehalose is added as protectants before lyophilization.

Reconstitution

Centrifuge the vial prior to opening. Reconstitute in sterile PBS, pH 7.4 to a concentration of 50 µg/mL. Do not vortex. This solution can be stored at 2-8°C for up to 1 month. For extended storage, it is recommended to store at -20°C.