CCT137690

Code: SML1237-5MG D2-231

Biochem/physiol Actions

CCT137690 is a very potent, orally bioavailble, pan aurora kinase inhbitor (IC50 = 15, 25, and 19 nM for Aurora A, B and C respectively). C...


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€166.70 5MG
€205.04 inc. VAT
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Biochem/physiol Actions

CCT137690 is a very potent, orally bioavailble, pan aurora kinase inhbitor (IC50 = 15, 25, and 19 nM for Aurora A, B and C respectively). CCT137690 inhibits tumor growth in amouse xenograft model and causes multipolar spindle formation, chromosome misalignment, polyploidy and apoptosis in tumor cell lines.

Packaging

5, 25 mg in glass bottle

assay≥98% (HPLC)
colorwhite to beige
formpowder
InChI keyGFLQCBTXTRCREJ-UHFFFAOYSA-N
InChI1S/C26H31BrN8O/c1-18-15-20(31-36-18)17-33-9-13-35(14-10-33)24-22(27)16-28-26-23(24)29-25(30-26)19-3-5-21(6-4-19)34-11-7-32(2)8-12-34/h3-6,15-16H,7-14,17H2,1-2H3,(H,28,29,30)
Quality Level100
SMILES stringCN(CC1)CCN1C(C=C2)=CC=C2C3=NC4=C(N5CCN(CC6=NOC(C)=C6)CC5)C(Br)=CN=C4N3
solubilityDMSO: 2 mg/mL, clear (warmed)
storage temp.−20°C
Cas Number1095382-05-0
This product has met the following criteria to qualify for the following awards:



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