CBR-5884

Code: SML1656-25MG D2-231

Application

CBR-5884 has been used as a 3-phosphoglycerate dehydrogenase (PHGDH) inhibitor to explore the role of PHGDH in Müller cells from different retinal regions and als...


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€522.80 25MG
€643.04 inc. VAT
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Application

CBR-5884 has been used as a 3-phosphoglycerate dehydrogenase (PHGDH) inhibitor to explore the role of PHGDH in Müller cells from different retinal regions and also used in trypan blue exclusion assay to determine the number of viable MYCN cells.

Biochem/physiol Actions

CBR-5884 is a cell penetrant, potent and selective noncompetitive inhibitor of 3-phosphoglycerate dehydrogenase (PHGDH) that inhibits proliferation of melanoma and breast cancer lines. CBR-5884 inhibits de novo serine synthesis in in cancer cells.

Packaging

5, 25 mg in glass bottle

assay≥98% (HPLC)
colorwhite to beige
formpaste
InChI keyQBVIRPJBDIZKBC-UHFFFAOYSA-N
InChI1S/C14H12N2O4S2/c1-3-19-14(18)11-8(2)10(21-7-15)13(22-11)16-12(17)9-5-4-6-20-9/h4-6H,3H2,1-2H3,(H,16,17)
Quality Level100
SMILES stringCC1=C(C(OCC)=O)SC(NC(C2=CC=CO2)=O)=C1SC#N
solubilityDMSO: 20 mg/mL, clear
storage temp.2-8°C
Cas Number681159-27-3
This product has met the following criteria to qualify for the following awards:



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