Application

CASIN has been used as a cell division control protein 42 homolog (Cdc42) inhibitor:to study its effects on the stimulation of extracellular vesicles (EVs) in intestinal epithelial cellsto study its effects on mice jejunumto study its effects on microbial adhesion-triggered endocytosis (MATE) vesicle morphology in segmented filamentous bacteria (SFB)-colonized mice

Biochem/physiol Actions

CASIN is an inhibitor of Cdc42 GTPase, a small GTPase of the Rho-subfamily that plays important roles in cytoskeleton organization, cell cycle progression, signal transduction, and vesicle trafficking. CASIN generated a rejuvenated phenotype of Hematopoietic stem cells (HSCs), reversing the aging-related and polarity phenotype of aged HSCs to that of young HSCs in vivo..

Packaging

5, 25 mg in glass bottle