Biochem/physiol Actions

Primary TargetHIV-integrase

Reversible: no

Product does not compete with ATP.

Cell permeable: yes

General description

A cell-permeable active component of propolis from honeybee hives. Known to have antiviral, anti-inflammatory, and immunomodulatory properties. An inhibitor of HIV-1 integrase activity. Inhibits the growth of different types of transformed cells. Has been reported to suppress lipid peroxidation. Inhibits ornithine decarboxylase, protein tyrosine kinase (PTK) and lipoxygenase activities. Also induces apoptosis in cloned rat embryo fibroblast (CREF) cells transformed by a number of different oncogenes. Has also recently been shown to act as a potent and specific inhibitor of NF-κB activation.

A cell-permeable active component of propolis from honeybee hives. Known to have antiviral, anti-inflammatory, and immunomodulatory properties. Has also recently been shown to act as a potent and specific inhibitor of NF-κB activation. An inhibitor of HIV-1 integrase activity. Inhibits the growth of different types of transformed cells. Has been reported to suppress lipid peroxidation. Inhibits ornithine decarboxylase, protein tyrosine kinase (PTK), and lipoxygenase activities. Also induces apoptosis in cloned rat embryo fibroblast (CREF) cells transformed by a number of different oncogenes.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Other Notes

Nicklaus, M.C., et al. 1997. J. Med. Chem.40, 920.Natarajan, K., et al. 1996. Proc. Natl. Acad. Sci. USA93, 9090.Burke, T.R., Jr., et al. 1995. J. Med. Chem. 38, 4171.Laranjinha, J., et al. 1995. Arch. Biochem. Biophys. 323, 373.Su, Z.-Z., et al. 1995. Anticancer Res. 15, 1841.Zheng, Z.S., et al. 1995. Oncol. Res. 7, 445.Su, Z.-Z., et al. 1994. Cancer Res. 54, 1865.Fesen, M.R., et al. 1993. Proc. Natl. Acad. Sci. USA90, 2399.Guarini, L., et al. 1992. Cell. Mol. Biol. 38, 513.

Packaging

Packaged under inert gas

25 mg in Plastic ampoule

Reconstitution

Following reconstitution aliquot and freeze at -20°C. Stock solutions are stable for up to 3 months at -20°C.

Warning

Toxicity: Irritant (B)