Biochem/physiol Actions

Primary TargetDAT/NET

General description

A non-selective inhibitor of dopamine and noradrenalin transporters (K_i = 1.4, 2.8 and 45 µM for dopamine, noradrenalin, and serotonin transporters respectively). Also an antagonist for neuronal nicotinic acetylcholine receptors (nAChrs) (IC₅₀ = 1.8 µM at α2β2 receptor). Clinically used as an antidepressant and smoking seceasion drug. Used in nicotinic addiction and depression studies.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Other Notes

Budzynska, B. et al. 2011 Pharmacol. Rep.63, 71.r>Dwoskin, P., et al. 2006. CNS Drug Rev.12, 178.Soroko, F., et al. 1977. J. Pharm. Pharmacol.29, 769.

Packaging

50 mg in Glass bottle

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Warning

Toxicity: Harmful (C)