Biochem/physiol Actions

Reversible: no

Product does not compete with ATP.

Target IC₅₀: 120 nM against 12-lipoxygenase

Cell permeable: yes

Primary Target12-lipoxygenase

General description

A cell-permeable flavone that inhibits the activity of 12-lipoxygenase (IC₅₀ = 120 nM) and reverse transcriptase. Reduces leukotriene biosynthesis and the release of lysosomal enzymes. Also inhibits cellular Ca²⁺ uptake and mobilization, and adjuvant-induces arthritis. Potentiates contractile responses to nerve stimulation. Inhibits protein tyrosine kinase and PMA-stimulated PKC.

A cell-permeable flavone that inhibits the activity of 12-lipoxygenase (IC₅₀ = 120 nM) and reverse transcriptase. Protects cortical neurons from β-amyloid induced toxicity. Reduces leukotriene biosynthesis and inhibits the release of lysosomal enzymes. Also inhibits cellular Ca²⁺ uptake and mobilization, and adjuvant-induced arthritis. Reported to inhibit microsomal lipid peroxidation by forming an iron-baicalein complex. Inhibits topoisomerase II and induces cell death in hepatocellular carcinoma cell lines. Potentiates contractile responses to nerve stimulation. Inhibits protein tyrosine kinase and PMA-stimulated protein kinase C.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Other Notes

Leabeau, A., et al. 2001. Neuroreport12, 2199.Gao, D., et al. 1996. Biochem. Mol. Biol. Int. 39, 215.Matsuzaki, Y., et al. 1996. Jpn. J. Cancer Res. 87, 170.Huang, H.C., et al. 1994. Eur. J. Pharmacol. 268, 73.Butenko, I.G., et al. 1993. Agents Actions 39, C49.Abe, K., et al. 1990. Chem. Pharm. Bull.38, 209.Kimura, Y., et al. 1987. Biochim. Biophys. Acta922, 278.Sekiya, K., and Okuda, H. 1982. Biochem. Biophys. Res. Commun.105, 1090.

Packaging

10 mg in Plastic ampoule

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.

Warning

Toxicity: Irritant (B)