Biochem/physiol Actions

Reversible: no

Product does not compete with ATP.

Primary TargetNADPH oxidase

Cell permeable: yes

General description

A cell-permeable, anti-inflammatory phenol that acts as a potent and selective inhibitor of NADPH oxidase. Also blocks peroxynitrite formation in murine macrophages. Reported to increase glutathione synthesis through the activation of AP-1. Shown to prevent phagocytosis of myelin by macrophages (10 mM).

A cell-permeable, anti-inflammatory phenolic compound that acts as a potent and selective inhibitor of NADPH oxidase. Shown to block peroxynitrite formation in murine macrophages. Reported to increase glutathione synthesis through activation of AP-1. Also reported to prevent phagocytosis of myelin by macrophages (10 mM).

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Other Notes

Abid, M.R., et al. 2000. FEBS Lett.486, 252.Muijsers, R.B., et al. 2000. Br. J. Pharmacol.130, 932.Lapperre, T.S., et al. 1999. FEBS Lett.443, 235.Supinski, G., et al. 1999, J. Appl. Physiol.87, 776.van der Goes, A., et al. 1998. J. Neuroimmunol.92, 67.Hart, B.A., and Simmons, J.M. 1992. Biotechnol. Ther.3, 3.

Packaging

Packaged under inert gas

1 g in Plastic ampoule

Reconstitution

Following reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Warning

Toxicity: Irritant (B)