Anti-ZC3H12A

Application

Anti-ZC3H12A Antibody detects level of ZC3H12A & has been published & validated for use in ZC3H12A.

Research Sub CategoryImmunoglobulins & Immunology

Research CategoryInflammation & Immunology

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

General description

Ribonuclease ZC3H12A, also known as MCP-induced protein 1 or Zinc finger CCCH domain-containing protein 12A, and encoded by the gene name ZC3H12A or MCPIP, is an essential member of a family of novel CCCH-zinc finger proteins that regulate macrophage activation. ZC3H12A may be involved in host immunity and inflammatory diseases. It has RNase activity that prevents some immune disorders by directly affecting the mRNA stability of interleukins such as IL-6 and IL12p40. Mice lacking the ZC3H12A gene suffered from severe anemia, and most dies within 12 weeks. Overexpression of ZC3H12A causes ER stress and induces a number of genes involved in apoptosis and autophagy, including JNK, PUMA, and beclin-1 in cardiac myoblasts, leading to cell death. ZC3H12A can also induce adipogenesis in 3T3-L1 pre-adipocytes in the absence of PPAPγ.

Immunogen

KLH-conjugated synthetic peptide corresponding to the center region of human ZC3H12A.

Epitope: center region

Other Notes

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Physical form

Antigen Affinity Purified

Purified rabbit polyclonal in buffer containing PBS with up to 0.1% sodium azide.

Quality

Evaluated by Western Blotting in Raji Cell lysate.

Western Blotting Analysis: 2 µg/mL of this antibody detected ZC3H12A in Raji Cell lysate.

Storage and Stability

Stable for 1 year at 2-8°C from date of receipt.

Target description

~75 kDa observed. Uncharacterized bands may be observed in some lysate(s).