Application

This Anti-Wnt-11 Antibody is validated for use in Western Blotting for the detection of Wnt-11.

General description

Wnt genes belong to a family of protooncogenes with at least 13 known members that are expressed in species ranging from Drosophila to man. Transcription of Wnt family genes appears to be developmentally regulated in a precise temporal and spatial manner. Wnt-11 activity is required for cells to undergo correct convergent extension movements during gastrulation. Wnt-11 is also expressed in the lung mesenchyme, the urorectal septum, the urogenital folds, the labioscrotal swellings, and the cortex of the adrenal gland. Unlike other Wnt family members, Wnt-11 is not expressed in the neuroepithelium of the central nervous system. Wnt-11, along with Wnt-8c, is expressed in the posterior region of the chick embryo in the caudal paraxial mesoderm that underlies the prospective caudal neural plate.

Immunogen

KLH-conjugated linear peptide corresponding to the C-terminus of Human Wnt-11.

Other Notes

Concentration: Please refer to lot specific datasheet.

Quality

Evaluated by Western Blot in human osteosarcoma U2OS cell lysate.
Western Blot Analysis: 0.5 µg/mL of this antibody detected WNT-11 in 10 µg of human osteosarcoma U2OS cell lysate.

Target description

~39 kDa observed