Application

Research CategoryApoptosis & Cancer

Research Sub CategoryApoptosis - Additional

Anti-VEGF-D Antibody detects level of VEGF-D & has been published & validated for use in VEGF-D.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

General description

VEGF-D, also known as Vascular Endothelial Growth Factor D, or c-Fos-induced growth factor, FIGF, and encoded by the gene FIGF/VEGFD, is one of a family of vascular growth factors that is active in angiogenesis, lymphangiogenesis and endothelial cell growth. VEGF-D functions during the formation of venous and lymphatic vascular systems and is critical for their maintenance during adulthood. VEGF-D, originally discovered as a c-Fos induced growth factor (FIGF), is developmentally regulated by c-Fos and expressed in a variety of tissues and organs including limb buds, acoustic ganglion, teeth, heart, anterior pituitary as well as lung and kidney mesenchyme, liver, derma, and periosteum of the vertebral column. Because of its role in lymphangiogenesis VEGFD is also a key therapeutic target to modulate metastasis, and recent research demonstrates that VEGFD-MEK-ERK signaling modulates SOX18-mediated transcription in normal cells and thus various pathologies maybe because of a dysregulation of SOXF-mediated transcriptional networks.

Immunogen

KLH-conjugated linear peptide corresponding to human VEGF-D near the N-terminus.

Epitope: Near N-terminus

Physical form

Affinity purified

Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

Quality

Evaluated by Western Blotting in SW620 cell lysate.

Western Blotting Analysis: 0.2 µg/mL of this antibody detected VEGF-D in 10 µg of SW620 cell lysate.

Storage and Stability

Stable for 1 year at 2-8°C from date of receipt.

Target description

~57 kDa observed. The calculated molecular weight is 40 kDa, however VEGF-D has been shown as a ~57 to ~58 kDa band in western blots (Liu Y.H., et al., (2008) J Immunol. 81(9):6584-94).