Application
Anti-SOX8 antibody produced in rabbit is suitable for western blotting at a concentration of 1 µg/ml.
Biochem/physiol Actions
Sox8 is expressed in Sertoli cells and regulates the spermatogenesis and spermatogenic cycle. Deficiency of Sox8 results in degeneration of adipose tissue and mild osteopenia.
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General description
Sox8 belongs to the SoxE family of transcription factors that are critical for development of neural crest cells. The Sox gene family has been implicated in a number of developmental disorders.
Immunogen
Synthetic peptide directed towards the C terminal region of human SOX8
Physical form
Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Sequence
Synthetic peptide located within the following region: ASPTETGPPRPHIKTEQPSPGHYGDQPRGSPDYGSCSGQSSATPAAPAGP
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