Application

Anti-SEC62 Antibody detects level of SEC62 & has been published & validated for use in SEC62.

Research CategoryApoptosis & Cancer

Immunohistochemistry Analysis: 5 µg/mL from a representative lot detected SEC62 in mouse brain tissue.

Research Sub CategoryApoptosis - Additional

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

General description

Translocation protein SEC62, also known as Translocation protein 1 (TP-1) or (hTP-1), and encoded by the gene name SEC62, is an integral membrane protein located in the rough endoplasmic reticulum (ER) and is part of the SEC61-SEC62-SEC63 complex. This complex is the central component of the protein translocation apparatus of the ER membrane. It is speculated that SEC61-SEC62-SEC63 may perform post-translational protein translocation into the ER and might also perform the backward transport of ER proteins that are subject to the ubiquitin-proteasome-dependent degradation pathway. Silencing of this gene with RNAi dramatically reduced the migration and invasive potential of numerous tumor cell lines, suggesting that it may be an attractive target for therapy of various tumors.

Immunogen

KLH-conjugated synthetic peptide corresponding to the C-terminus of human SEC62.

Epitope: C-terminus

Other Notes

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Physical form

Antigen Affinity Purified

Purified rabbit polyclonal in buffer containing PBS with up to 0.1% sodium azide.

Quality

Evaluated by Western Blotting in rat brain tissue lysate.

Western Blotting Analysis: 0.5 µg/mL of this antibody detected SEC62 in rat brain tissue lysate.

Specificity

This antibody is predicted to not cross-react with other SEC proteins.

Storage and Stability

Stable for 1 year at 2-8°C from date of receipt.

Target description

~31 and ~43 kDa observed. Uncharacterized bands may be observed in some lysate(s).