Anti-PDE4D3

Code: ABN117 D2-231

Analysis Note

ControlMouse brain membrane tissue lysate

Application

Research CategoryNeuroscience

Research Sub CategoryDevelopmental Neuros...


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€386.00 EACH
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Analysis Note

ControlMouse brain membrane tissue lysate

Application

Research CategoryNeuroscience

Research Sub CategoryDevelopmental Neuroscience

This Anti-PDE4D3 Antibody is validated for use in WB for the detection of PDE4D3.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

General description

Phosphodiesterase 4D3 (PDE4D3) is a member of the PDE cyclic nucleotides. PDE4D3 is known to be regulated by protein kinase C (PKC)-Raf-MEK-ERK and also by cAMP in vascular smooth muscle cells. PDE4D3 is a direct target of the MSH/cAMP/MITF pathway and may play a role in melanocyte differentiation. PDE4D3 is essential to have equilibrium in relaxing and contracting cues to airway smooth muscle. Down-regulation of PDE4D3 may be associated with analgesic and anti-inflammatory effects. PDE4D3 has also been linked to the risk of stroke, and in particular to polygenic stroke.

Immunogen

KLH-conjugated linear peptide corresponding to the N-terminus of human PDE4D3.

Epitope: N-terminus

Other Notes

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Physical form

Affinity purified

Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

Quality

Evaluated by Western Blot in mouse brain membrane tissue lysate.

Western Blot Analysis: 1 µg/mL of this antibody detected PDE4D3 on 10 µg of mouse brain membrane tissue lysate.

Specificity

This antibody recognizes PDE4D3 at the N-terminus.

Storage and Stability

Stable for 1 year at 2-8°C from date of receipt.

Target description

~95 kDa observed. UniProt describes 12 isoforms produced by alternative splicing.

antibody formaffinity isolated antibody
antibody product typeprimary antibodies
biological sourcerabbit
clonepolyclonal
Gene Informationhuman ... PDE4D(5144)
NCBI accession no.NP_006194
purified byaffinity chromatography
Quality Level100
shipped inwet ice
species reactivity (predicted by homology)rhesus monkey (based on 100% sequence homology), human (immunogen homology)
species reactivityrhesus macaque, mouse, rat
technique(s)western blot: suitable
UniProt accession no.Q08499
This product has met the following criteria to qualify for the following awards:



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