Application

Detect the NIPSNAP protein using this Anti-NIPSNAP validated for use in WB & IHC.

Immunohistochemistry Analysis: 2.5 µg/mL of this antibody from a representative lot detected NIPSNAP in human brain tissue.

General description

NIPSNAP is a member of an evolutionarily well conserved gene family and has a strong sequence similarity to the central portion of a protein encoded by C. elegans chromosome III between a 4-nitrophenylphosphatase (NIP) domain and non-neuronal SNAP25-like protein. Recent studies have indicated that NIPSNAP is involved in the regulation of the Ca2+-selective transient receptor potential vanilloid channel 6 (TRPV6). NIPSNAP1 associates with TRPV6 at the plasma membrane and inhibits TRPV6 currents. Other studies show that NIPSNAP's expression is reduced in the phenylketonuria (PKU) brain, suggesting that NIPSNAP may play a role in memory.

Immunogen

KLH-conjugated linear peptide corresponding to human NIPSNAP.

Other Notes

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Quality

Evaluated by Western Blot in human brain tissue lysate.

Western Bloting Analysis: 1 µg/mL of this antibody detected NIPSNAP in 15 µg of human brain tissue lysate.

Target description

~33 kDa observed