Analysis Note

ControlK562 cell lysate

Application

Research CategoryApoptosis & Cancer

Anti-MORF4 Antibody is a highly specific rabbit polyclonal antibody, that targets Mortality factor 4 & has been tested in western blotting, IHC & Immunofluorescence.

Immunohistochemistry Analysis: 5 µg/mL from a representative lot detected MORF4 in human brain tissue.

Immunofluorescence Analysis: 20 µg/mL from a representative lot detected MORF4 in HepG2 cells.

Research Sub CategoryApoptosis - Additional

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

General description

Mortality factor 4 (MORF4) is a component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes typically by acetylation of nucleosomal histones H4 and H2A. NuA4 complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, DNA repair and apoptosis. MORF4 is localized to the nucleus and has transcription factor-like motifs such as helix-loop-helix and a leucine zipper motif. Additionally, MORF4 has been shown to bind to the transcription corepressors mSin3A and TLE, suggesting that together, these complexes may play a role in transcriptional repression of genes that lead to cellular senescence.

Immunogen

KLH-conjugated linear peptide corresponding to human MORF4.

Other Notes

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Physical form

Antigen Affinity Purified

Purified rabbit polyclonal in buffer containing PBS with up to 0.1% sodium azide.

Quality

Evaluated by Western Blotting in K562 cell lysate

Western Blotting Analysis: 2 µg/mL of this antibody detected MORF4 in 15 µg of K562 cell lysate.

Storage and Stability

Stable for 1 year at 2-8°C from date of receipt.

Target description

~33 kDa observed