Application

Anti-LRRTM1 Antibody detects level of LRRTM1 & has been published & validated for use in LRRTM1.

Research CategoryNeuroscience

Research Sub CategoryDevelopmental Neuroscience

Immunohistochemistry Analysis: 5 µg/mL from a representative lot detected LRRTM1 in human brain tissue.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

General description

Leucine-rich repeat transmembrane neuronal protein 1 (LRRTM1) exhibits strong synaptogenic activity that is restricted to excitatory presynaptic differentiation that acts at both pre- and postsynaptic levels. LRRTMs are differentially expressed in the nervous system and were recently found to instruct presynaptic and mediate postsynaptic glutamatergic differentiation, with LRRTM1 and LRRTM2 most potent at inducing presynaptic differentiation. Each LRRTM protein is a type I transmembrane containing ten extracellular leucine-rich repeats and a short intracellular tail and has a developmentally regulated pattern distinct from all others. LRRTM1 is a maternally suppressed gene that is associated paternally with handedness and schizophrenia.

Immunogen

KLH-conjugated synthetic peptide corresponding to the C-terminus of human LRRTM1.

Epitope: C-terminus

Other Notes

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Physical form

Antigen Affinity Purified

Purified rabbit polyclonal in buffer containing PBS with up to 0.1% sodium azide.

Quality

Evaluated by Western Blotting in mouse brain tissue lysate with and without blocking peptide.

Western Blotting Analysis: 1 µg/mL of this antibody detected LRRTM1 in mouse brain tissue lysate.

Storage and Stability

Stable for 1 year at 2-8°C from date of receipt.

Target description

~70 kDa observed. Uncharacterized bands may be observed in some lysate(s).