Analysis Note

ControlHuman brain tissue lysate

Application

Research Sub CategoryCytoskeleton

Immunohistochemistry Analysis: 10 µg/mL from a representative lot detected KLHL1 in rat brain tissue.

Research CategoryCell Structure

Detect Kelch-like 1 using this rabbit polyclonal antibody, Anti-KLHL1 Antibody validated for use in western blotting & IHC.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

General description

The mammalian Kelch-like 1 (KLHL1) was initially discovered as a homolog to the Drosophila Kelch gene that is highly expressed in several brain tissues. KLHL1 contains one BTB (POZ) domain and six Klech repoeats. KLHL1 may play an important role in organizing the actin cytoskeleton of the brain cells. Mutations associated with KLHL1 are inplicated in spinocerebellar ataxia type 8 (SCA8).

Immunogen

KLH-conjugated linear peptide corresponding to human KLHL1.

Other Notes

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Physical form

Antigen Affinity Purified

Purified rabbit polyclonal in buffer containing PBS with up to 0.1% sodium azide.

Quality

Evaluated by Western Blotting in human brain tissue lysate.

Western Blotting Analysis: 4 µg/mL of this antibody detected KLHL1 in 15 µg/mL of human brain tissue lysate.

Storage and Stability

Stable for 1 year at 2-8°C from date of receipt.

Target description

~100 kDa observed