Application

This Anti-IFITM1 Antibody is validated for use in western blotting, ICC & immunofluorescence for the detection of IFITM1.

Research CategoryApoptosis & Cancer

Immunocytochemistry Analysis: 20 µg/mL from a representative lot detected IFITM1 in Jurkat cells.

Immunofluorescence Analysis: 20 µg/mL from a representative lot detected IFITM1 in Jurkat cells.

Research Sub CategoryApoptosis - Additional

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

General description

Interferon-induced transmembrane protein 1, also known as Dispanin subfamily A member 2a (DSPA2a) or Interferon-induced protein 17 or Interferon-inducible protein 9-27 or Leu-13 antigen or CD225, and encoded by the gene name IFITM1 or CD225 is a member of the IFN-inducible transmembrane protein family. It is an essential mediator of interferon-γ-induced antiproliferation and plays a role in the control of cell growth and migration. IFITM1 is upregulated in several tumor types and may be useful as a tumor biomarker. Both mouse IFITM1 and IFITM3 are expressed on the cell surfaces of primordial germ cells in a developmentally-regulated manner. IFITM1 activity is required for primordial germ cell transit, and IFITM1 acts as a repulsive molecule by repelling non-IFITM1-expressing primordial germ cells from the mesoderm into the endoderm.

Immunogen

Epitope: center region

KLH-conjugated synthetic peptide corresponding to the center region of human IFITM1.

Other Notes

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Physical form

Antigen Affinity Purified

Purified rabbit polyclonal in buffer containing PBS with up to 0.1% sodium azide.

Quality

Evaluated by Western Blotting in NIH/3T3 cell lysate.

Western Blotting Analysis: 2 µg/mL of this antibody detected IFITM1 in NIH/3T3 cell lysate.

Specificity

This antibody will cross-react with IFITM2 and IFITM3.

Storage and Stability

Stable for 1 year at 2-8°C from date of receipt.

Target description

~14 kDa observed. Uncharacterized bands may be observed in some lysate(s).