Application

Detect HAVcr-1 using this Anti-HAVcr-1 Antibody validated for use in western blotting & flow cytometry.

Flow Cytometry Analysis: 1 µg from a representative lot detected HAVcr-1 in 1X10E6 769-P cells.

Research CategoryInflammation & Immunology

Research Sub CategoryInflammation & Autoimmune Mechanisms

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

General description

T-cell immunoglobulin and mucin domain-containing protein 1 (TIMD-1, TIM-1, TIM, TIM1, TIMD1), also known as Hepatitis A virus cellular receptor 1 (HAVcr-1) and Kidney injury molecule 1(KIM-1, KIM1), may play an important role in T-helper cell development and the regulation of asthma and allergic diseases. In the case of human hepatitis A virus (HHAV) infection, HAVcr-1 functions as a cell-surface receptor for the virus, through which the hepatitis A virus can gain entry into a cell. Additional evidence implies that it may play a role in kidney injury and repair. HAVcr-1 is widely expressed, with highest levels in kidney and testis. It is also expressed by activated CD4+ T-cells during the development of helper T-cells responses. Furthermore, HAVcr-1 is expressed on T helper 2 (Th2) cells of the immune system, and following the binding of its natural ligand TIM-4, stimulates T cell expansion and cytokine production in response to viral challenge.

Immunogen

KLH-conjugated linear peptide corresponding to human HAVcr-1.

Other Notes

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Physical form

Affinity purified

Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

Quality

Evaluated by Western Blotting in human spleen tissue lysate.

Western Blotting Analysis: 1 µg/mL of this antibody detected HAVcr-1 in 10 µg of human spleen tissue lysate.

Storage and Stability

Stable for 1 year at 2-8°C from date of receipt.

Target description

~59 kDa observed. Uniprot describes a molecular weight at 38 kDa However, this protein has been observed at ~59 kDa (Thompson, P., et al. (1998). J Virol. 72(5):3751-3761.).