Anti-GluR1

Code: ABN241 D2-231

Application

Anti-GluR1 Antibody is a highly specific rabbit polyclonal antibody, that targets GluR1 & has been tested in western blotting & IHC (Paraffin).

Immunohistoc...


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€516.00 EACH
€634.68 inc. VAT

Application

Anti-GluR1 Antibody is a highly specific rabbit polyclonal antibody, that targets GluR1 & has been tested in western blotting & IHC (Paraffin).

Immunohistochemistry Analysis: A 1:1,000 dilution from a representative lot detected GluR1 in human brain and human cerebellum tissue.

General description

Glutamate receptors (GluRs) are a diverse group responsible for mediating most of the excitatory synaptic transmission in the CNS of vertebrates. They can be categorized as ionotropic or metabotropic and subcategorized by their agonist preferences (NMDA, AMPA or Kainic acid). There are four types of AMPA selective GluR subunits (GluR1, GluR2, GluR3 and GluR4). Tetrameric or pentameric combinations of different subunits contributes to the functional diversity of AMPA receptors. AMPA receptors mediate fast synaptic current at most excitatory synapses, with stoichiometry characterized by subtype composition. The critical residue controlling calcium permeability is in the pore loop region. In GluR1, GluR3, and GluR4, this position is occupied by a Gln residue. The insertion or removal of GluR1/GluR4 oligomeric channels from postsynaptic membranes appears to be LTP/LTD activity dependent while GluR2/GluR3 oligomers are continuously cycling.

Immunogen

KLH-conjugated linear peptide corresponding to the extracellular domain of rat GluR1.

Linkage

Replaces: PC246-100UG

Other Notes

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Quality

Evaluated by Western Blotting in rat brain tissue lysate.

Western Blotting Analysis: 2.0 µg/mL of this antibody detected GluR1 in 10 µg of rat brain tissue lysate.

Specificity

This antibody recognizes the extracellular domain of GluR1.

Target description

~110 kDa observed

antibody formaffinity isolated antibody
antibody product typeprimary antibodies
biological sourcerabbit
clonepolyclonal
Gene Informationhuman ... GRIA1(2890)mouse ... Gria1(14799)rat ... Gria1(50592)
NCBI accession no.NP_113796
purified byaffinity chromatography
Quality Level100
shipped inwet ice
species reactivityrat, mouse, human
technique(s)western blot: suitable, immunohistochemistry: suitable (paraffin)
UniProt accession no.P19490
This product has met the following criteria to qualify for the following awards:



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