AV40487-100UL Display Image

Anti-EIF4G3

Code: AV40487-100UL D2-231

Application

Anti-EIF4G3 polyclonal antibody is used to tag eukaryotic translation initiation factor 4 gamma 3 proteins for detection and quantitation by Western blotting and ...


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€577.00 100UL

Application

Anti-EIF4G3 polyclonal antibody is used to tag eukaryotic translation initiation factor 4 gamma 3 proteins for detection and quantitation by Western blotting and in cells and tissues by immunohistochemical (IHC) techniques. It is used as a probe to study the role of eukaryotic translation initiation factor 4 gamma 3 in the initiation of mRNA translation and as a target of CTL cells during infectious virus assault.

Biochem/physiol Actions

EIF4G3 is probable component of the protein complex eIF4F, which is involved in the recognition of the mRNA cap, ATP-dependent unwinding of 5′-terminal secondary structure and recruitment of mRNA to the ribosome. It is thought to be a functional homolog of EIF4G1.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

General description

Eukaryotic translation initiation factor 4 gamma 3 (EIF4G3) is involved in protein translation within the mammalian mRNA ribosome complex. EIF4G3 has been shown to be a target of cytotoxic T lymphocyte (CTL) produced granzyme B (GrB) suggesting that EIF4G3 may be targeted by CTL cells as a mechanism to inhibit the use of host translational machinery by infectious viruses.

Immunogen

Synthetic peptide directed towards the N terminal region of human EIF4G3

Physical form

Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

Sequence

Synthetic peptide located within the following region: TAASDQKQEEKPKPDPVLKSPSPVLRLVLSGEKKEQEGQTSETTAIVSIA

Specificity

Anti-EIF4G3 polyclonal antibody reacts with human, mouse, rat, and bovine eukaryotic translation initiation factor 4 gamma 3 proteins.

antibody formaffinity isolated antibody
antibody product typeprimary antibodies
biological sourcerabbit
clonepolyclonal
concentration0.5 mg - 1 mg/mL
conjugateunconjugated
formbuffered aqueous solution
Gene Informationhuman ... EIF4G3(8672)
mol wt57 kDa
NCBI accession no.NP_003751
Quality Level100
shipped inwet ice
species reactivityhuman
storage temp.−20°C
technique(s)western blot: suitable
UniProt accession no.O43432-2
Quantity
Est. Dispatch/Availability