Analysis Note

ControlA549 cell lysate

Application

This Anti-DSCR3 Antibody is validated for use in WB, IH(P) for the detection of DSCR3.

Research Sub CategoryNeurodegenerative Diseases

Research CategoryNeuroscience

Immunohistochemistry Analysis: A 1:200 dilution from a representative lot detected DSCR3 in human gastric tissue.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

General description

Trisomy of human chromosome 21 result in patients with Down′s syndrome, which is a complex developmental and neurodegenerative disease that is characterized with abnormal morphological features, hypotonia, and mental retardation. The DSCR3 (Down syndrome critical region gene 3) gene is found in this region. DSCR3 expresses Down syndrome critical region protein 3, which is reportedly expressed in many studied tissues. While it is suggested that this protein is involved in neuroexcitation and in cellular signaling, further study is still required to elucidate its role and mechanism of action.

Immunogen

KLH-conjugated linear peptide corresponding to human DSCR3.

Other Notes

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Physical form

Affinity purified

Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

Quality

Evaluated by Western Blot in A549 cell lysate.

Western Blot Analysis: 0.5 µg/mL of this antibody detected DSCR3 in 10 µg of A549 cell lysate.

Specificity

Other homologies: Rat and Mouse (92% sequence homology).

Storage and Stability

Stable for 1 year at 2-8°C from date of receipt.

Target description

~39 kDa observed. An uncharacterized band may be observed at a molecular weight of ~160 kDa in some cell lysates.