Anti-DOM3Z

Code: ABE1306 D2-231

Application

Anti-DOM3Z is an antibody against DOM3Z for use in Western Blotting.

General description

Decapping and exoribonuclease protein (DOM3Z...


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Your Price
€377.00 EACH
€463.71 inc. VAT

Application

Anti-DOM3Z is an antibody against DOM3Z for use in Western Blotting.

General description

Decapping and exoribonuclease protein (DOM3Z), also known as DXO, Dom-3 homolog Z, and encoded by the gene symbol DOM3Z/ DOM3L/ NG6, is a ribonuclease that specifically degrades pre-mRNAs with a defective 5′ end cap. DOM3Z is part of a pre-mRNA capping quality control and has decapping, pyrophosphohydrolase and 5′-3′ exonuclease activities. DOM3Z has a decapping activity toward incomplete 5′ end cap mRNAs (such as unmethylated 5′ end-capped RNA), which in return releases GpppN and 5′ end monophosphate RNA. The 5′ end monophosphate RNA is then degraded by the 5′-3′ exoribonuclease activity, enabling this enzyme to decap and degrade incompletely capped mRNAs. Additionally, DOM3Z has been implied to have RNA 5′-pyrophosphohydrolase activity and to release pyrophosphates by hydrolyzing the 5′ end triphosphate. DOM3Z is located in the nucleus, and expressed ubiquitously.

Immunogen

KLH-conjugated linear peptide corresponding to human DOM3Z.

Other Notes

Concentration: Please refer to lot specific datasheet.

Quality

Evaluated by Western Blotting in human pancreas tissue lysate.

Western Blotting Analysis: 1.0 µg/mL of this antibody detected DOM3Z in 10 µg of human pancreas tissue lysate.

Target description

~45 kDa observed

antibody formaffinity isolated antibody
antibody product typeprimary antibodies
biological sourcerabbit
clonepolyclonal
Gene Informationhuman ... DXO(1797)
NCBI accession no.NP_005501
purified byaffinity chromatography
Quality Level100
shipped inwet ice
species reactivity (predicted by homology)bovine (based on 100% sequence homology)
species reactivityhuman, rat, mouse
technique(s)western blot: suitable
UniProt accession no.O77932
This product has met the following criteria to qualify for the following awards:



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