Biochem/physiol Actions

CXCL6 (C-X-C motif chemokine ligand 6)/GCP-2 (granulocyte chemotactic protein-2) plays an important role in the recruitment and activation of neutrophils. It acts as an autocrine growth factor resulting in tumor progression and metastasis. CXCL6 participates in menstruation, implantation and the maintenance of early pregnancy. GCP-2 plays an important role in mucosal chronic inflammatory conditions like inflammatory bowel disease or chronic rhinosinusitis.

Features and Benefits

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General description

CXCL6 (C-X-C motif chemokine ligand 6)/GCP-2 (granulocyte chemotactic protein-2), a pro-inflammatory neutrophil chemoattractant, is mapped to human chromosome 4q12-q13. It belongs to the ELR⁺ CXC family. It is synthesized by mesenchymal cells like fibroblasts and micro and macrovascular endothelial cells.

Immunogen

Synthetic peptide of human CXCL6

Physical form

Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.