Analysis Note
ControlNIH/3T3 cell lysate
Application
Research CategoryStem Cell Research
Anti-BMPR-1A Antibody is an antibody against BMPR-1A for use in WB.
Research Sub CategoryKinases & Phosphatases
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
General description
BMPR-1A (bone morphogenic protein receptor type 1A) signaling is known to be important for inner root sheath differentiation, hair follicle cycling and tooth development. Mutations in BMPR-1A are a common cause of juvenile polyposis syndrome (JPS). BMPR-1A is expressed in a high quantity during the formation of the primary and secondary palate and the loss of BMPR-1A could be a cause for the cleft palate birth defect.
Immunogen
Epitope: Extracellular domain
KLH-conjugated linear peptide corresponding to the extracellular domain of human BMPR-1A.
Other Notes
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
Physical form
Affinity purified
Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Quality
Evaluated by Western Blot in NIH/3T3 cell lysate.
Western Blot Analysis: 0.1 µg/mL of this antibody detected BMPR-1A on 10 µg of NIH/3T3 cell lysate.
Specificity
This antibody recognizes BMPR-1A at the extracellular domain.
Storage and Stability
Stable for 1 year at 2-8°C from date of receipt.
Target description
~75 kDa observed. The calculated molecular weight is 67 kDa; however, BMPR-1A has been shown as a ~77 kDa band in western blots (Koenig, B., et al. (1994). Molecular and Cellular Biology. 14(9):5961-5974).
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