Application

Anti-ANP32E antibody produced in rabbit is suitable for western blotting at a concentration of 0.25µg/ml. It is also useful for immunohistochemistry at a concentration of 4-8µg/ml.

Biochem/physiol Actions

ANP32E [Acidic (leucine-rich) Nuclear phosphoprotein 32 family, member E] also referred to as LANP-L, LANPL or MGC5350 is a histone chaperone located on chromosome 1q22 and is primarily expressed in human peripheral blood leukocytes, colon, small intestine, prostate, thymus, spleen, skeletal muscle, liver and kidney. It facilitates the genome-wide removal of histone H2A.Z/H2AFZ from the nucleosome. It also blocks the activity of protein phosphatase 2A (PP2A) but not the protein phosphatase 1. Additionally, it may play a pivotal role in cerebellar development and synaptogenesis.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Immunogen

Synthetic peptide directed towards the middle region of human ANP32E

Physical form

Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

Sequence

Synthetic peptide located within the following region: EDNEAPDSEEEDDEDGDEDDEEEEENEAGPPEGYEEEEEEEEEEDEDEDE