Anaphase-Promoting Complex Inhibitor; TAME

Code: 172104-50MG D2-231

General description

TAME is a potent ubiquitin ligase inhibitor that specifically blocks Anaphase-Promoting Complex (APC) activation by directly binding to APC and disrupts t...


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General description

TAME is a potent ubiquitin ligase inhibitor that specifically blocks Anaphase-Promoting Complex (APC) activation by directly binding to APC and disrupts the IR-tail-dependent interactions between APC and its activator proteins Cdc20 or Cdh1. It stabilizes APC substrates and is shown to inhibit cyclin proteolysis in mitotic Xenopus egg extract with an IC50 = 12 µM.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Other Notes

Sackton, K.L., et al. 2014. Nature. In press.Zeng, X., et al. 2010. Cancer Cell18, 382.

Packaging

Packaged under inert gas

50 mg in Glass bottle

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Warning

Toxicity: Standard Handling (A)

assay≥98% (HPLC)
colorwhite
formsolid
InChI keyJIQFFACVQXXHMY-UHFFFAOYSA-N
InChI1S/C14H22N4O4S.ClH/c1-10-5-7-11(8-6-10)23(20,21)18-12(13(19)22-2)4-3-9-17-14(15)16;/h5-8,12,18H,3-4,9H2,1-2H3,(H4,15,16,17);1H
manufacturer/tradenameCalbiochem®
Quality Level100
shipped inambient
solubilityDMSO: 50 mg/mL
storage conditionprotect from light, OK to freeze
storage temp.2-8°C
Cas Number1784-03-8
This product has met the following criteria to qualify for the following awards:



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