AZ3146

Code: SML1427-25MG D2-231

Biochem/physiol Actions

AZ3146 is a potent and specific inhibitor of monopolar spindle 1 kinase (Mps1; IC50 = 35 nM), an important regulator of Spindle Assembly Ch...


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Your Price
€696.27 25MG
Discontinued
€856.41 inc. VAT

Biochem/physiol Actions

AZ3146 is a potent and specific inhibitor of monopolar spindle 1 kinase (Mps1; IC50 = 35 nM), an important regulator of Spindle Assembly Checkpoint (SAC). AZ3146 treated HeLa cells override SAC, and quickly enter mitosis, with a reduced mitosis completion time of 32 minutes. 50% of treated cells entered anaphase without complete chromosomal alignment.

Packaging

5, 25 mg in glass bottle

assay≥98% (HPLC)
colorwhite to light brown
formpowder
InChI keyYUKWVHPTFRQHMF-UHFFFAOYSA-N
InChI1S/C24H32N6O3/c1-28-12-10-17(11-13-28)33-18-8-9-19(21(14-18)32-3)26-23-25-15-20-22(27-23)30(24(31)29(20)2)16-6-4-5-7-16/h8-9,14-17H,4-7,10-13H2,1-3H3,(H,25,26,27)
Quality Level100
SMILES stringCN1CCC(OC2=CC(OC)=C(NC3=NC=C4C(N(C5CCCC5)C(N4C)=O)=N3)C=C2)CC1
solubilityDMSO: 2 mg/mL, clear (warmed)
storage temp.2-8°C
Cas Number1124329-14-1
This product has met the following criteria to qualify for the following awards:



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