Analysis Note

ControlMouse kidney tissue lysate

Application

Research Sub CategoryImmunological Signaling

Anti-UHRF1BP1 Antibody is a highly specific rabbit polyclonal antibody, that targets UHRF1-binding protein 1 & has been tested in western blotting & IHC.

Research CategoryInflammation & Immunology

Immunohistochemistry Analysis: 2.5 µg/mL from a representative lot detected UHRF1BP1 in human kidney tissue.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

General description

UHRF1-binding protein 1 (UHRF1BP1), also known as ICBP90-binding protein 1 and Ubiquitin-like containing PHD and RING finger domains 1-binding protein 1, is a transcription and cell cycle regulator. UHRF1BP1 is required for proper heterochromatin formation in mammalian cells and may act as a negative regulator of cell growth. UHRF1BP1 is implied to be an important target for the ERK1/2 signaling pathway to control the proliferation of Jurkat T cells. Additionally, UHRF1BP1 binds to the histone H3 N-terminal tail when methylated on K9 by two functional domains, a PHD finger and an SRA (SET- and RING-associated) domain. The PHD finger defines the binding specificity and an SRA domain promotes binding activity.

Immunogen

KLH-conjugated linear peptide corresponding to human UHRF1BP1.

Other Notes

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Physical form

Antigen Affinity Purified

Purified rabbit polyclonal in buffer containing PBS with up to 0.1% sodium azide.

Quality

Evaluated by Western Blotting in mouse kidney tissue lysate.

Western Blotting Analysis: 2 µg/mL of this antibody detected UHRF1BP1 in 15 µg of mouse kidney tissue lysate.

Storage and Stability

Stable for 1 year at 2-8°C from date of receipt.

Target description

~80 kDa observed. Uncharacterized bands may appear in some lysate(s).