Analysis Note

ControlMouse brain nuclear extract

Application

Research Sub CategoryRNA Metabolism & Binding ProteinsHistonesRNA Binding Protein (RBP)

Research CategoryProtein TraffickingEpigenetics & Nuclear Function

Anti-SMRTe Antibody is a high quality Rabbit Polyclonal Antibody for the detection of SMRTe & has been validated in ChIP, ICC & WB.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

General description

SMRT is 1495 amino acids and contains an 8 amino acid sequence that is not present in SMRTe (SMRT-extended), which contains 2514 amino acids. SMRTe contains an N-terminal sequence spanning over 1,000 amino acids that is not present in SMRT, but that shows significant similarity with N-CoR. SMRTe expression is regulated during cell cycle progression, suggesting a role for SMRTe in the regulation of cycle-specific gene expression in diverse signaling pathways.

Immunogen

GST fusion-protein corresponding to residues 1146-1349 of human SMRTe

Legal Information

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

Physical form

Protein A chromatography

0.1M Tris-glycine, pH 7.4, 0.15M NaCl, 0.05% sodium azide before the addition of glycerol to 30%

Format: Purified

Quality

routinely evaluated by immunoblot on nuclear fraction from murine brain

Specificity

SMRT isoforms

Storage and Stability

Store at 2–8°C

Target description

270kDa, 180kDa and 80kDa