Anti-Slc22A17

Application

Immunofluorescence Analysis: 20 µg/mL from a representative lot detected Slc22A17 in rat kidney tissue.

Anti-Slc22A17 Antibody is an antibody against Slc22A17 for use in western blotting & immunofluorescence.

General description

Solute carrier family 22 member 17, also known as 24p3 receptor (24p3R) or Brain-type organic cation transporter or Lipocalin-2 receptor or Neutrophil gelatinase-associated lipocalin receptor (NgalR), and encoded by the gene name SLC22A17 or BOCT or BOIT, is a family of organic anion and cation transporters (OATs, OCTs, OCTNs) that are expressed in brain. Each contain 12 predicted alpha-helical transmembrane domains (TMDs) and one large extracellular loop between TMDs 1 and 2. Transporters of the SLC22 family function in different ways such as uniporters that mediate facilitated diffusion in either direction (OCTs), as anion exchangers (OAT1, OAT3 and URAT1), and as Na(+)/l-carnitine cotransporter (OCTN2). Slc22 family members participate in the absorption and/or excretion of drugs, xenobiotics, and endogenous compounds in intestine, liver, and kidney, and perform homeostatic functions in brain and heart. Mutations in the Slc22 family may cause specific diseases such as primary systemic carnitine deficiency or idiopathic renal hypouricemia and may change drug absorption or excretion. Recent studies show the expression of Slc22A17 as receptor for Lipocalin 2 is relatively high in hematopoietic stem cells.

Immunogen

KLH-conjugated synthetic peptide corresponding to the C-terminus of human Slc22A17.

Other Notes

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Quality

Evaluated by Western Blotting in SK-N-SH cell lysate with and without blocking peptide.

Western Blotting Analysis: 1 µg/mL of this antibody detected Slc22A17 in SK-N-SH cell lysate with and without blocking peptide.

Target description

~60 kDa observed. Uncharacterized bands may be observed in some lysate(s).