Application

Anti-SCRN1 Antibody is an antibody against SCRN1 for use in western blotting, IHC & immunofluorescence.

Research CategoryApoptosis & Cancer

Research Sub CategoryApoptosis - Additional

Immunohistochemistry Analysis: 5 µg/mL from a representative lot detected SCRN1 in human kidney tissue.

Immunofluorescence Analysis: 20 µg/mL from a representative lot detected SCRN1 in human kidney cells.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

General description

Secernin-1 (SCRN1) is involved in the regulation of exocytosis from peritoneal mast cells. More recent studies have shown that SCRN1 expression is upregulated in gastric cancer cell lines and may possess epitopes that could function as tumor-associated antigens, potentially providing targets for cancer vaccines in the treatment of gastric cancers. Another report indicates that decreased expression of SCRN1 via RNAi expression resulted in significantly lower rates of cell growth in colorectal cancer cell lines, and increased SCRN1 expression in patients with colorectal cancer correlated with poor prognosis, suggesting that SCRN1 may also be involved in the regulation of cell growth and might be useful as a prognostic tool.

Immunogen

Epitope: C-terminus

KLH-conjugated synthetic peptide corresponding to the C-terminus of human SCRN1.

Other Notes

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Physical form

Antigen Affinity Purified

Purified rabbit polyclonal in buffer containing PBS with up to 0.1% sodium azide.

Quality

Evaluated by Western Blotting in human kidney tissue with and without blocking peptide.

Western Blotting Analysis: 1 µg/mL of this antibody detected SCRN1 in human kidney tissue with and without blocking peptide.

Storage and Stability

Stable for 1 year at 2-8°C from date of receipt.

Target description

~30 and ~48 kDa observed. Uncharacterized bands may be observed in some lysate(s).