Application

This Anti-PRDM14 Antibody is validated for use in WB for the detection of PRDM14.

General description

PR domain proteins (PRDMs) have been associated with many types of human cancers. PRDM14 was found to be up-regulated in breast cancer cells. The expression of PRDM14 to breast cancer cells actually increased cell proliferation and decreased the effect of chemotherapeutic drugs, while down-regulation of PRDM14 did the opposite. In addition to breast cancer, PRDM14 has recently been linked to non-small cell lung cancer development. PRDM14 also seems to play a role in the preservation of the self-renewal of human embryonic stem cells and transcriptional regulation.

Immunogen

GST-tagged recombinant protein corresponding to the N-terminus of human PRDM14.

Quality

Evaluated by Western Blot in human lung tissue lysate.

Western Blot Analysis: A 1:1000 dilution of this antibody detected PRDM14 in 10 µg of human lung tissue lysate.

Specificity

This antibody recognizes the N-terminus of PRDM14.

Target description

~62 kDa observed