Biochem/physiol Actions

PKD2L1 (polycystin 2 like 1, transient receptor potential cation channel) participates in hedgehog signaling, intestinal development and sour tasting. It controls ciliary Ca2⁺ concentration. Mutations in PKD2 results in autosomal dominant kidney disease (ADPKD).

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General description

PKD2L1 (polycystin 2 like 1, transient receptor potential cation channel) is also known as polycystin-L/ transient receptor potential polycystin-3 (TRPP3). It is expressed in brain, kidney, heart, skeletal muscle, spleen, testis, retina and in the bipolar neurons in the tongue taste buds. TRPP3 is present on the surface membrane and/or endoplasmic reticulum membrane of cells. It belongs to the PKD2 gene family. PKD2L1 is mapped to human chromosome 10q25.

Immunogen

Synthetic peptide of human PKD2L1

Physical form

Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.