Application

Detect the PANK2 protein using this Anti-PANK2 validated for use in WB.

General description

PANK2 (Pantothenate kinase 2) phosphorylates pantothenic acid (vitamin B(5) and regulates the overall rate of coenzyme A (CoA) biosynthesis. PANK2 thereby plays an important role in lipid metabolism and energy production. Mutation or knockdown of the PANK2 gene results in various disease states, including hypoglycemia, hyperketonemia, faulty metabolism, poor postnatal development, and childhood neurodegeneration.

Immunogen

KLH-conjugated linear peptide corresponding to human PANK2.

Other Notes

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Quality

Evaluated by Western Blot in human hippocampus tissue lysate.

Western Blot Analysis: 1.0 µg/mL of this antibody detected PANK2 in 10 µg of human hippocampus tissue lysate.

Specificity

This antibody demonstrates specificity for isoform 1, but does not cross react with other isoforms.

Target description

~62/37 kDa observed. Uncharacterized bands may appear at ~15 kDa, ~25 kDa, and ~260 kDa in some lysates. The calculated molecular weight is 62 kDa, however PANK2 has been shown as a ~40 kDa band in western blots (Kotzbauer, P. T., et al. (2005). The Journal of Neuroscience. 25(3):689-698).