Application

Anti-NEMF antibody produced in rabbit is suitable for immunohistochemistry at a dilution of 1:25 - 1:100 and western blot at a dilution of 1:200-1:1000.

Biochem/physiol Actions

Nuclear export mediator factor (NEMF) is involved in the recruitment of Listerin to stalled ribosomes. It forms a complex with the nascent chain-containing 60S-Listerin and recruits and stabilizes Listerin’;s N-terminal domain. It plays a vital role in mediating nuclear export. Inactivation of Sdccag1 expression leads to the transformation of human lung cancer cells.

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General description

Nuclear export mediator factor (NEMF), also known as Sdccag1 (Serologically Defined Colon Cancer Antigen 1) encodes a protein exhibiting tumor suppression property.It consists of four prominent domains: the N- and C-lobe connected by a coiled-coil to the middle (M) domain.

Immunogen

Synthetic peptide corresponding to a region derived from internal residues of human nuclear export mediator factor

Physical form

Rabbit IgG in pH7.3 PBS, 0.05% NaN₃, 50% Glycerol.

Specificity

The antibody detects endogenous levels of total NEMF protein.